Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency
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چکیده
منابع مشابه
Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency
We report a simple model that predicts the maximum recommended therapeutic dose (MRTD) of small molecule drugs based on an assessment of likely protein-drug interactions. Previously, we reported methods for computational estimation of drug promiscuity and potency. We used these concepts to build a linear model derived from 238 small molecular drugs to predict MRTD. We applied this model success...
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ژورنال
عنوان ژورنال: Clinical and Translational Science
سال: 2016
ISSN: 1752-8054,1752-8062
DOI: 10.1111/cts.12422